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Try these steps to fix the “Steam must be running to play this game” error for Devil May Cry (Steam):

Restart basics

Close Steam completely (right‑click tray icon → Exit). Open Steam as Administrator (right‑click → Run as administrator). Launch the game from Steam.

Verify the game is launched from Steam

In Steam, go to Library → Devil May Cry → Play. Avoid launching the game via its .exe or a desktop shortcut before Steam is open.

Disable compatibility flags

Right‑click the game’s exe (steamapps/common/Devil May Cry/... or via Properties → Local Files → Browse). Properties → Compatibility → uncheck “Run this program in compatibility mode” and “Run this program as an administrator.” Apply.

Verify integrity of game files

Steam Library → right‑click game → Properties → Local Files → Verify integrity of game files.

Disable conflicting overlays / programs

In Steam: Settings → In‑Game → uncheck “Enable the Steam Overlay.” Close other overlays (Discord, NVIDIA GeForce Experience, MSI Afterburner). Temporarily disable antivirus/firewall or add Steam and the game folder as exceptions.

Check Steam launch options and install path

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